(2-Thienylmethyl)amine → HCID 131726364, compound

HRID 1349033Notes

Reaction equation

HRID 1349033 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[N:19]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=1)=C=O.[S:30]1[CH:34]=[CH:33][CH:32]=[C:31]1[CH2:35][NH2:36]>>[CH3:15][O:14][N:13]=[C:11]1[CH2:12][N:8]([C:6]([NH:19][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=2)=[O:7])[C@H:9]([C:16]([NH:36][CH2:35][C:31]2[S:30][CH:34]=[CH:33][CH:32]=2)=[O:18])[CH2:10]1

Participants

4

Reactant 3

HCID 34005(2-Thienylmethyl)amineHCID 878433-Methoxyphenyl isocyanateHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726364HCID 131726364, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1-isocyanato-3-methoxybenzene, and 2-thienylmethylamine the title compound was obtained in 79% purity by LC/MS. MS(ESI+): m/z=403.2.

Sources & evidence

ORD record
ord-668a957acabf42dc86c71824a5fe765f
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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