1-Piperonylpiperazine → HCID 131725418, compound

HRID 1349034Notes

Reaction equation

HRID 1349034 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[N:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=C=O.[O:27]1[C:31]2[CH:32]=[CH:33][C:34]([CH2:36][N:37]3[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]3)=[CH:35][C:30]=2[O:29][CH2:28]1>>[O:27]1[C:31]2[CH:32]=[CH:33][C:34]([CH2:36][N:37]3[CH2:38][CH2:39][N:40]([C:16]([C@@H:9]4[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]4[C:6]([NH:19][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[O:7])=[O:18])[CH2:41][CH2:42]3)=[CH:35][C:30]=2[O:29][CH2:28]1

Participants

4

Reactant 3

HCID 944261-PiperonylpiperazineHCID 206036Pentane, 1-isocyanato-HCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725418HCID 131725418, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 1-(1,3-benzodioxol-5-ylmethyl)piperazine the title compound was obtained in 72% purity by LC/MS. MS(ESI+): m/z=474.4.

Sources & evidence

ORD record
ord-fe74673144e34b699de3fd9d0d5b6a3a
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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