HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → (2S,4EZ)-4-(tert-butoxyimino)-N2-cyclopropyl-N1-(3,5-dichlorophenyl)-1,2-pyrrolidinedicarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 3,5-Dichlorophenyl isocyanate | HCID 94460 | — |
| Reactant | (2S,4EZ)-1-(tertbutoxycarbonyl)-4-(tert-butoxyimino)-2-pyrrolidinecarboxylic acid | HCID 131725425 | — |
| Product | (2S,4EZ)-4-(tert-butoxyimino)-N2-cyclopropyl-N1-(3,5-dichlorophenyl)-1,2-pyrrolidinedicarboxamide | HCID 131725424 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(tert-butoxyimino)-2-pyrrolidinecarboxylic acid, 1,3-dichloro-5-isocyanatobenzene, and cyclopropylamine the title compound was obtained in 48% purity by LC/MS. MS(ESI+): m/z=427.6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211601B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-46f4fa17c6074fcb8164acbe8a27d52f |
| Source note | uspto-grants-2007_05 |