(2-Thienylmethyl)amine → HCID 131726367, compound

HRID 1349044Notes

Reaction equation

HRID 1349044 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[N:19]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=1)=C=O.[S:29]1[CH:33]=[CH:32][CH:31]=[C:30]1[CH2:34][NH2:35]>>[CH3:15][O:14][N:13]=[C:11]1[CH2:12][N:8]([C:6]([NH:19][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[CH:23]=2)=[O:7])[C@H:9]([C:16]([NH:35][CH2:34][C:30]2[S:29][CH:33]=[CH:32][CH:31]=2)=[O:18])[CH2:10]1

Participants

4

Reactant 3

HCID 34005(2-Thienylmethyl)amineHCID 69303m-Tolyl isocyanateHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726367HCID 131726367, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 1-isocyanato-3-methylbenzene, and 2-thienylmethylamine the title compound was obtained in 98% purity by LC/MS. MS(ESI+): m/z=387.2.

Sources & evidence

ORD record
ord-06d2607c3af242e3965b725bff13650d
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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