HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,4-Dichlorophenyl)piperazine → (3EZ,5S)-5-{[4-(3 4-dichlorophenyl)-1-piperazinyl]carbonyl}-1-[(2-oxo-6-pentyl-2H-pyran-3-yl)carbonyl]-3-pyrrolidinone O-benzyloxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| Reactant | 2-oxo-6-pentyl-2H-pyran-3-carbonyl chloride | HCID 22223512 | — |
| Reactant | (2S,4EZ)-4[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid | HCID 131725420 | — |
| Product | (3EZ,5S)-5-{[4-(3 4-dichlorophenyl)-1-piperazinyl]carbonyl}-1-[(2-oxo-6-pentyl-2H-pyran-3-yl)carbonyl]-3-pyrrolidinone O-benzyloxime | HCID 131726369 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from (2S,4EZ)-4[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2H-pyran-3-carbonyl chloride, and 1-(3,4-dichlorophenyl)piperazine the title compound was obtained in 47% purity by LC/MS. MS(ESI+): m/z=639.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211601B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-2c45a507a5a04e2fa762badf48a6d69d |
| Source note | uspto-grants-2007_05 |