p-Chlorophenoxyacetyl chloride → HCID 131725433, compound

HRID 1349051Notes

Reaction equation

HRID 1349051 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])(C)(C)C.[Cl:18][C:19]1[CH:29]=[CH:28][C:22]([O:23][CH2:24]C(Cl)=O)=[CH:21][CH:20]=1.[Cl:30][C:31]1[CH:32]=[C:33]([N:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)[CH:34]=[CH:35][C:36]=1[Cl:37]>>[Cl:14][CH:13]=[C:11]1[CH2:12][N:8]([C:6](=[O:7])[CH2:24][O:23][C:22]2[CH:21]=[CH:20][C:19]([Cl:18])=[CH:29][CH:28]=2)[C@H:9]([C:15]([N:41]2[CH2:40][CH2:39][N:38]([C:33]3[CH:34]=[CH:35][C:36]([Cl:37])=[C:31]([Cl:30])[CH:32]=3)[CH2:43][CH2:42]2)=[O:17])[CH2:10]1

Participants

4

Reactant 3

HCID 77771p-Chlorophenoxyacetyl chlorideHCID 936011-(3,4-Dichlorophenyl)piperazineHCID 69251379HCID 69251379, compound

Product 1

HCID 131725433HCID 131725433, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, (4-chlorophenoxy)acetyl chloride, and 1-(3,4-dichlorophenyl)piperazine the title compound was obtained in 64% purity by LC/MS. MS(ESI+): m/z=543.6.

Sources & evidence

ORD record
ord-a60bcdeb8c694a6b8b3e80f7f046f222
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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