HRID1349052

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID118946

4,6-Dimethoxy-2-pyrimidinamine

C6H9N3O2

HCID22223512

未命名化合物

结构：CC(C)(C)OC(=O)N1CC(=NOCc2ccccc2)C[C@H]1C(=O)O

HCID131725420

未命名化合物

PRODUCTS

生成物

结构：CCCCCc1ccc(C(=O)N2CC(=NOCc3ccccc3)C[C@H]2C(=O)Nc2nc(OC)cc(OC)n2)c(=O)o1

HCID131725434

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2H-pyran-3-carbonyl chloride, and 4,6-dimethoxy-2-pyrimidinamine the title compound was obtained in 62% purity by LC/MS. MS(ESI+): m/z=564.6.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d4744a0ddfe54ae4bf9d60ff3586a8f7
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07211601B2
来源说明: uspto-grants-2007_05

反应 SMILES

[CH2:1]([O:8][N:9]=[C:10]1[CH2:14][N:13]([C:15]([O:17]C(C)(C)C)=O)[C@H:12]([C:22]([OH:24])=O)[CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:25]=[C:26]1[C:31](C(Cl)=O)=[CH:30][CH:29]=[C:28]([CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[O:27]1.[CH3:40][O:41][C:42]1[CH:47]=[C:46]([O:48][CH3:49])[N:45]=[C:44]([NH2:50])[N:43]=1>>[CH2:1]([O:8][N:9]=[C:10]1[CH2:14][N:13]([C:15]([C:31]2[C:26](=[O:25])[O:27][C:28]([CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[CH:29][CH:30]=2)=[O:17])[C@H:12]([C:22]([NH:50][C:44]2[N:43]=[C:42]([O:41][CH3:40])[CH:47]=[C:46]([O:48][CH3:49])[N:45]=2)=[O:24])[CH2:11]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1