HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,1,3-Benzothiadiazol-4-amine → (2S)-N2-(2,1,3-benzothiadiazol-4-yl)-N1-(3,5-dichlorophenyl)-4-oxo-1,2-pyrrolidinedicarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,1,3-Benzothiadiazol-4-amine | HCID 69845 | — |
| Reactant | 3,5-Dichlorophenyl isocyanate | HCID 94460 | — |
| Reactant | (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid | HCID 11593804 | — |
| Product | (2S)-N2-(2,1,3-benzothiadiazol-4-yl)-N1-(3,5-dichlorophenyl)-4-oxo-1,2-pyrrolidinedicarboxamide | HCID 69247735 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from l-(tert-butoxy-carbonyl)-4-oxoproline, 1,3-dichloro-5-isocyanatobenzene, and 2,1,3-benzothiadiazol-4-amine the title compound was obtained in 47% purity by LC/MS. MS(ESI+): m/z=450.6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211601B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-d2207107f7364d6d85e12ceafbe4a1ff |
| Source note | uspto-grants-2007_05 |