HRID1349061

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID80123

2-(1H-Pyrrol-1-yl)aniline

C10H10N2

HCID84151

[1,1'-Biphenyl]-4-carbonyl chloride

C13H9ClO

结构：CC(C)(C)OC(=O)N1CC(=NOCc2ccc(Cl)c(Cl)c2)C[C@H]1C(=O)O

HCID131725417

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccccc1-n1cccc1)[C@@H]1CC(=NOCc2ccc(Cl)c(Cl)c2)CN1C(=O)c1ccc(-c2ccccc2)cc1

HCID131725436

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4carbonyl chloride, and 2-(1H-pyrrol-1-yl)phenylamine the title compound was obtained in 54% purity by LC/MS. MS(ESI+): m/z=623.6.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c24d51bb29d74b7d90e21a1e9706761e
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07211601B2
来源说明: uspto-grants-2007_05

反应 SMILES

C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=2)[CH2:10][C@H:9]1[C:24]([OH:26])=O)=[O:7])(C)(C)C.[C:27]1([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH:32]=[CH:31][C:30](C(Cl)=O)=[CH:29][CH:28]=1.[N:42]1([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=2[NH2:53])[CH:46]=[CH:45][CH:44]=[CH:43]1>>[C:36]1([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:37]=[CH:38][C:39]([C:6]([N:8]2[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=3)[CH2:10][C@H:9]2[C:24]([NH:53][C:48]2[CH:49]=[CH:50][CH:51]=[CH:52][C:47]=2[N:42]2[CH:46]=[CH:45][CH:44]=[CH:43]2)=[O:26])=[O:7])=[CH:40][CH:41]=1