(2-Thienylmethyl)amine → (2S,4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-1-(diphenylacetyl)-N-(2-thienylmethyl)-2-pyrrolidinecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	(2-Thienylmethyl)amine	HCID 34005	—
Reactant	2,2-Diphenylacetyl chloride	HCID 74637	—
Reactant	(2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid	HCID 131725417	—
Product	(2S,4EZ)-4-{[(3,4-dichlorobenzyl)oxy]imino}-1-(diphenylacetyl)-N-(2-thienylmethyl)-2-pyrrolidinecarboxamide	HCID 131725437	—

Reaction Steps

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, diphenylacetyl chloride, and 2-thienylmethylamine the title compound was obtained in 51% purity by LC/MS. MS(ESI+): m/z=592.6

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07211601B2
Source dataset	uspto-grants-2007_05
ORD ID	ord-3891405a61ae40ca916a66d77157a7c9
Source note	uspto-grants-2007_05