Benzo-1,3-dioxole-5-methylamine → HCID 131725440, compound

HRID 1349065Notes

Reaction equation

HRID 1349065 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[CH2:10][C@H:9]1[C:24]([OH:26])=O)=[O:7])(C)(C)C.[N:27]([CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=C=O.[O:35]1[C:39]2[CH:40]=[CH:41][C:42]([CH2:44][NH2:45])=[CH:43][C:38]=2[O:37][CH2:36]1>>[O:35]1[C:39]2[CH:40]=[CH:41][C:42]([CH2:44][NH:45][C:24]([C@@H:9]3[CH2:10][C:11](=[N:13][O:14][CH2:15][C:16]4[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=4)[CH2:12][N:8]3[C:6]([NH:27][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[O:7])=[O:26])=[CH:43][C:38]=2[O:37][CH2:36]1

Participants

4

Reactant 3

HCID 75799Benzo-1,3-dioxole-5-methylamineHCID 206036Pentane, 1-isocyanato-HCID 58714542HCID 58714542, compound

Product 1

HCID 131725440HCID 131725440, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 1,3-benzodioxol-5-ylmethylamine the title compound was obtained in 63% purity by LC/MS. MS(ESI+): m/z=511.4.

Sources & evidence

ORD record
ord-028f49c3a7184a8d8affbd77eb9fe746
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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