6-Aminoquinoline → HCID 69250423, compound

HRID 1349078Notes

Reaction equation

HRID 1349078 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])(C)(C)C.[C:18]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:23]=[CH:22][C:21](C(Cl)=O)=[CH:20][CH:19]=1.[N:33]1[C:42]2[C:37](=[CH:38][C:39]([NH2:43])=[CH:40][CH:41]=2)[CH:36]=[CH:35][CH:34]=1>>[C:27]1([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:28]=[CH:29][C:30]([C:6]([N:8]2[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]2[C:15]([NH:43][C:39]2[CH:38]=[C:37]3[C:42](=[CH:41][CH:40]=2)[N:33]=[CH:34][CH:35]=[CH:36]3)=[O:17])=[O:7])=[CH:31][CH:32]=1

Participants

4

Reactant 3

HCID 113736-AminoquinolineHCID 841514-Phenylbenzoyl chlorideHCID 69251379HCID 69251379, compound

Product 1

HCID 69250423HCID 69250423, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbo-nyl chloride, and 6-quinolinamine the title compound was obtained in 73% purity by LC/MS. MS(ESI+): m/z=468.4.

Sources & evidence

ORD record
ord-0e99b063beee43fc8ad5c05e09f8a5dd
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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