Veratrylamine → HCID 69250384, compound

HRID 1349080Notes

Reaction equation

HRID 1349080 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][Cl:14])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])(C)(C)C.[O:18]=[C:19]1[C:24](C(Cl)=O)=[CH:23][CH:22]=[C:21]([CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[O:20]1.[CH3:33][O:34][C:35]1[CH:36]=[C:37]([CH:40]=[CH:41][C:42]=1[O:43][CH3:44])[CH2:38][NH2:39]>>[Cl:14][CH:13]=[C:11]1[CH2:12][N:8]([C:6]([C:24]2[C:19](=[O:18])[O:20][C:21]([CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[CH:22][CH:23]=2)=[O:7])[C@H:9]([C:15]([NH:39][CH2:38][C:37]2[CH:40]=[CH:41][C:42]([O:43][CH3:44])=[C:35]([O:34][CH3:33])[CH:36]=2)=[O:17])[CH2:10]1

Participants

4

Reactant 3

HCID 79832VeratrylamineHCID 222235122-oxo-6-pentyl-2H-pyran-3-carbonyl chlorideHCID 69251379HCID 69251379, compound

Product 1

HCID 69250384HCID 69250384, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(chloromethylene)-2-pyrrolidinecarboxylic acid, 2-oxo-6-pentyl-2H-pyran-3-carbonyl chloride, and 3,4-dimethoxybenzylamine the title compound was obtained in 51% purity by LC/MS. MS(ESI+): m/z=503.4.

Sources & evidence

ORD record
ord-c5d11e10a9554b1898310e2bdda933bf
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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