N,N-Diethylethylenediamine → (2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]-imino}-N-[2-(diethylamino)ethyl]-2-pyrrolidinecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	N,N-Diethylethylenediamine	HCID 60993	—
Reactant	4-Phenylbenzoyl chloride	HCID 84151	—
Reactant	(2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid	HCID 131725417	—
Product	(2S,4EZ)-1-([1,1'-biphenyl]-4-ylcarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]-imino}-N-[2-(diethylamino)ethyl]-2-pyrrolidinecarboxamide	HCID 131725460	—

Reaction Steps

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(3,4-dichlorobenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and N1,N1-diethyl-1,2-ethanediamine the title compound was obtained in 74% purity by LC/MS. MS(ESI+): m/z=581.6.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07211601B2
Source dataset	uspto-grants-2007_05
ORD ID	ord-3c7bbc1690cb4504bc05bc1d0ce8df15
Source note	uspto-grants-2007_05