HRID1349119

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8588

3-Amino-9-ethylcarbazole

C14H14N2

HCID84151

[1,1'-Biphenyl]-4-carbonyl chloride

C13H9ClO

结构：CC(C)(C)OC(=O)N1CC(=CC#N)C[C@H]1C(=O)O

HCID69250314

未命名化合物

PRODUCTS

生成物

结构：CCn1c2ccccc2c2cc(NC(=O)[C@@H]3CC(=CC#N)CN3C(=O)c3ccc(-c4ccccc4)cc3)ccc21

HCID69249541

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 32% purity by LC/MS. MS(ESI+): m/z=525.4.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-31ccb2e26b1d4253893d53bec648f438
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07211601B2
来源说明: uspto-grants-2007_05

反应 SMILES

C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][C:14]#[N:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:22](C(Cl)=O)=[CH:21][CH:20]=1.[CH2:34]([N:36]1[C:48]2[CH:47]=[CH:46][C:45]([NH2:49])=[CH:44][C:43]=2[C:42]2[C:37]1=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH3:35]>>[C:28]1([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:29]=[CH:30][C:31]([C:6]([N:8]2[CH2:12][C:11](=[CH:13][C:14]#[N:15])[CH2:10][C@H:9]2[C:16]([NH:49][C:45]2[CH:46]=[CH:47][C:48]3[N:36]([CH2:34][CH3:35])[C:37]4[C:42]([C:43]=3[CH:44]=2)=[CH:41][CH:40]=[CH:39][CH:38]=4)=[O:18])=[O:7])=[CH:32][CH:33]=1