O-Phenylenediamine → HCID 69250041, compound

HRID 1349132Notes

Reaction equation

HRID 1349132 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[CH:13][C:14]#[N:15])[CH2:10][C@H:9]1[C:16](O)=O)=[O:7])(C)(C)C.[O:19]([C:26]1[CH:34]=[CH:33][C:29](C(Cl)=O)=[CH:28][CH:27]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[C:35]1([NH2:42])[C:36]([NH2:41])=[CH:37][CH:38]=[CH:39][CH:40]=1>>[NH:41]1[C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=2[N:42]=[C:16]1[CH:9]1[N:8]([C:6](=[O:7])[C:29]2[CH:28]=[CH:27][C:26]([O:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[CH:34][CH:33]=2)[CH2:12][C:11](=[CH:13][C:14]#[N:15])[CH2:10]1

Participants

4

Reactant 3

HCID 7243O-PhenylenediamineHCID 741934-Phenoxybenzoyl chlorideHCID 69250314(2S,4EZ)-1-(tertbutoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid

Product 1

HCID 69250041HCID 69250041, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tertbutoxycarbonyl)-4-(cyanomethylene)-2-pyrrolidinecarboxylic acid, 4-phenoxybenzoyl chloride, and 1,2-benzenediamine the title compound was obtained in 90% purity by LC/MS. MS(ESI+): m/z=421.2.

Sources & evidence

ORD record
ord-8f49fdd9f4264c80a0c2adb7fab8da55
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

Loading…