HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl isocyanate → (2S,4EZ)-N2-(2,1,3-benzothiadiazol-4-yl)-4-[(benzyloxy)imino]-N1-phenyl-1,2-pyrrolidinedicarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | 2,1,3-Benzothiadiazol-4-amine | HCID 69845 | — |
| Reactant | (2S,4EZ)-4[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid | HCID 131725420 | — |
| Product | (2S,4EZ)-N2-(2,1,3-benzothiadiazol-4-yl)-4-[(benzyloxy)imino]-N1-phenyl-1,2-pyrrolidinedicarboxamide | HCID 131725488 | — |
Reaction Steps
Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(benzyloxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, isocyanatobenzene, and 2,1,3-benzothiadiazol-4-amine the title compound was obtained in 57% purity by LC/MS. MS(ESI+): m/z=487.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07211601B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-de83893d5c80405c8d5b4a79538a02eb |
| Source note | uspto-grants-2007_05 |