3-Methoxyphenyl isocyanate → HCID 69250764, compound

HRID 1349165Notes

Reaction equation

HRID 1349165 reaction equation
C(O[C:6]([N:8]1[CH2:15][C:14](=[O:16])[CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])(C)(C)C.[N:17]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=1)=C=O.[NH:28]1[CH2:31][CH:30]([OH:32])[CH2:29]1>>[OH:32][CH:30]1[CH2:31][N:28]([C:10]([C@@H:9]2[CH2:13][C:14](=[O:16])[CH2:15][N:8]2[C:6]([NH:17][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=2)=[O:7])=[O:12])[CH2:29]1

Participants

4

Reactant 3

HCID 878433-Methoxyphenyl isocyanateHCID 15142903-HydroxyazetidineHCID 11593804(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid

Product 1

HCID 69250764HCID 69250764, compound

Procedure

Following the general method as outlined in Example 22, starting from 1-(tert-butoxycarbonyl)-4-oxoproline, 1-isocyanato-3-methoxybenzene, and 3-azetidinol the title compound was obtained in 87% purity by LC/MS. MS(ESI+): m/z=334.2.

Sources & evidence

ORD record
ord-77b419de41f34f25a33fc35662599e59
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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