2-(1H-pyrrol-1-yl)aniline → HCID 131725523, compound

HRID 1349170Notes

Reaction equation

HRID 1349170 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][CH3:16])[CH2:10][C@H:9]1[C:17]([OH:19])=O)=[O:7])(C)(C)C.[N:20]([CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=C=O.[N:28]1([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=2[NH2:39])[CH:32]=[CH:31][CH:30]=[CH:29]1>>[CH2:15]([O:14][N:13]=[C:11]1[CH2:12][N:8]([C:6]([NH:20][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[O:7])[C@H:9]([C:17]([NH:39][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[N:28]2[CH:29]=[CH:30][CH:31]=[CH:32]2)=[O:19])[CH2:10]1)[CH3:16]

Participants

4

Reactant 3

HCID 801232-(1H-pyrrol-1-yl)anilineHCID 206036Pentane, 1-isocyanato-HCID 58714540(2S,4EZ)-1-(tertbutoxycarbonyl)-4-(ethoxyirnino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725523HCID 131725523, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, 1-isocyanatopentane, and 2-(1H-pyrrol-1-yl)phenylamine the title compound was obtained in 83% purity by LC/MS. MS(ESI+): m/z=426.2.

Sources & evidence

ORD record
ord-8367ea314c2c4891af882629c6ad2198
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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