6-Aminoquinoline → HCID 131725530, compound

HRID 1349177Notes

Reaction equation

HRID 1349177 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[O:19]([CH2:26]C(Cl)=O)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[N:30]1[C:39]2[C:34](=[CH:35][C:36]([NH2:40])=[CH:37][CH:38]=2)[CH:33]=[CH:32][CH:31]=1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:12][N:8]([C:6](=[O:7])[CH2:26][O:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C@H:9]([C:16]([NH:40][C:36]2[CH:35]=[C:34]3[C:39](=[CH:38][CH:37]=2)[N:30]=[CH:31][CH:32]=[CH:33]3)=[O:18])[CH2:10]1

Participants

4

Reactant 3

HCID 113736-AminoquinolineHCID 69703Phenoxyacetyl chlorideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725530HCID 131725530, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, phenoxyacetyl chloride, and 6-quinolinamine the title compound was obtained in 100% purity by LC/MS. MS(ESI+): m/z=419.2.

Sources & evidence

ORD record
ord-7269c647e19c433ab3ee54931f22837e
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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