3-Amino-9-ethylcarbazole → HCID 131725541, compound

HRID 1349188Notes

Reaction equation

HRID 1349188 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][CH3:16])[CH2:10][C@H:9]1[C:17]([OH:19])=O)=[O:7])(C)(C)C.[Cl:20][C:21]1[CH:26]=[C:25]([N:27]=C=O)[CH:24]=[C:23]([Cl:30])[CH:22]=1.[CH2:31]([N:33]1[C:45]2[CH:44]=[CH:43][C:42]([NH2:46])=[CH:41][C:40]=2[C:39]2[C:34]1=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH3:32]>>[Cl:20][C:21]1[CH:26]=[C:25]([NH:27][C:6]([N:8]2[CH2:12][C:11](=[N:13][O:14][CH2:15][CH3:16])[CH2:10][C@H:9]2[C:17]([NH:46][C:42]2[CH:43]=[CH:44][C:45]3[N:33]([CH2:31][CH3:32])[C:34]4[C:39]([C:40]=3[CH:41]=2)=[CH:38][CH:37]=[CH:36][CH:35]=4)=[O:19])=[O:7])[CH:24]=[C:23]([Cl:30])[CH:22]=1

Participants

4

Reactant 3

HCID 85883-Amino-9-ethylcarbazoleHCID 944603,5-Dichlorophenyl isocyanateHCID 58714540(2S,4EZ)-1-(tertbutoxycarbonyl)-4-(ethoxyirnino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725541HCID 131725541, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(ethoxyimino)-2-pyrrolidinecarboxylic acid, 1,3-dichloro-5-isocyanatobenzene, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 43% purity by LC/MS. MS(ESI+): m/z=552.6.

Sources & evidence

ORD record
ord-7b84d3953bf24a808881e9704ebd215e
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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