3-Amino-9-ethylcarbazole → HCID 131726378, compound

HRID 1349193Notes

Reaction equation

HRID 1349193 reaction equation
[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11]([O:13]C(C)(C)C)=O)[C@H:8]([C:18]([OH:20])=O)[CH2:7]1)[CH:2]=[CH2:3].[CH3:21][O:22][CH2:23]C(Cl)=O.[CH2:27]([N:29]1[C:41]2[CH:40]=[CH:39][C:38]([NH2:42])=[CH:37][C:36]=2[C:35]2[C:30]1=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH3:28]>>[CH2:1]([O:4][N:5]=[C:6]1[CH2:10][N:9]([C:11](=[O:13])[CH2:23][O:22][CH3:21])[C@H:8]([C:18]([NH:42][C:38]2[CH:39]=[CH:40][C:41]3[N:29]([CH2:27][CH3:28])[C:30]4[C:35]([C:36]=3[CH:37]=2)=[CH:34][CH:33]=[CH:32][CH:31]=4)=[O:20])[CH2:7]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 85883-Amino-9-ethylcarbazoleHCID 96623Methoxyacetyl chlorideHCID 58714562(2S,4EZ)-4-[(allyloxy)imino)-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726378HCID 131726378, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-4-[(allyloxy)-imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid, methoxyacetyl chloride, and 9-ethyl-9H-carbazol-3-amine the title compound was obtained in 74% purity by LC/MS. MS(ESI+): m/z=449.2.

Sources & evidence

ORD record
ord-a0a7dfe0dc054e80abe3323ac1861906
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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