Pentane, 1-isocyanato- → HCID 22223653, compound

HRID 1349198Notes

Reaction equation

HRID 1349198 reaction equation
C(O[C:6]([N:8]1[CH2:15][C:14](=[CH2:16])[CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])(C)(C)C.[N:17]([CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=C=O.[NH2:25][CH:26]1[CH2:29][N:28]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:27]1>>[CH2:16]=[C:14]1[CH2:15][N:8]([C:6]([NH:17][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[O:7])[CH:9]([C:10]([NH:25][CH:26]2[CH2:27][N:28]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:29]2)=[O:12])[CH2:13]1

Participants

4

Reactant 3

HCID 206036Pentane, 1-isocyanato-HCID 1516507Tert-butyl 3-aminoazetidine-1-carboxylateHCID 21727417(2S)-1-((tert-butoxy)carbonyl)-4-methylidenepyrrolidine-2-carboxylic acid

Product 1

HCID 22223653HCID 22223653, compound

Procedure

Following the general method as outlined in Example 22, starting from 1-(tert-butoxycarbonyl)-4-methyleneproline, 1-isocyanatopentane, and tert-butyl 3-amino-1-azetidinecarboxylate the title compound was obtained in 75% purity by LC/MS. MS(ESI+): m/z=395.2.

Sources & evidence

ORD record
ord-b6b6072589b949b697c315156040b602
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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