4-Phenoxybenzoyl chloride → HCID 131725552, compound

HRID 1349202Notes

Reaction equation

HRID 1349202 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[CH2:10][C@H:9]1[C:24]([OH:26])=O)=[O:7])(C)(C)C.[O:27]([C:34]1[CH:42]=[CH:41][C:37](C(Cl)=O)=[CH:36][CH:35]=1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[N:43]1([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][C:49]=2[NH2:54])[CH:47]=[CH:46][CH:45]=[CH:44]1>>[CH3:23][O:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][O:14][N:13]=[C:11]2[CH2:12][N:8]([C:6](=[O:7])[C:37]3[CH:36]=[CH:35][C:34]([O:27][C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)=[CH:42][CH:41]=3)[C@H:9]([C:24]([NH:54][C:49]3[CH:50]=[CH:51][CH:52]=[CH:53][C:48]=3[N:43]3[CH:47]=[CH:46][CH:45]=[CH:44]3)=[O:26])[CH2:10]2)=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 741934-Phenoxybenzoyl chlorideHCID 801232-(1H-pyrrol-1-yl)anilineHCID 58714542HCID 58714542, compound

Product 1

HCID 131725552HCID 131725552, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidinecarboxylic acid, 4-phenoxybenzoyl chloride, and 2-(1H-pyrrol-1-yl)phenylamine the title compound was obtained in 55% purity by LC/MS. MS(ESI+): m/z=601.4.

Sources & evidence

ORD record
ord-a8f065478cb84d95bf3597487bb4dd84
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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