Phenylethanolamine → HCID 131726381, compound

HRID 1349232Notes

Reaction equation

HRID 1349232 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=O)(C)(C)C.[C:19]([C:27]1[CH:35]=[CH:34][C:30](C(O)=O)=[CH:29][CH:28]=1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[NH2:36][CH2:37][CH:38]([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[OH:39]>>[C:19]([C:20]1[CH:21]=[CH:22][C:23]([CH2:6][N:8]2[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]2[C:16]([NH:36][CH2:37][CH:38]([OH:39])[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[O:18])=[CH:24][CH:25]=1)(=[O:26])[C:27]1[CH:28]=[CH:29][CH:30]=[CH:34][CH:35]=1

Participants

4

Reactant 3

HCID 1000PhenylethanolamineHCID 691474-Benzoylbenzoic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726381HCID 131726381, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-benzoylbenzoic acid, and (1RS)-2-amino-1-phenylethanol, the title compound was obtained in 93% purity by HPLC. MS(ESI+): m/z=486.

Sources & evidence

ORD record
ord-27d319b3a2924f239353ffbaa0157406
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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