HRID1349242

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID951

(+/-)-Norepinephrine

C8H11NO3

HCID84151

[1,1'-Biphenyl]-4-carbonyl chloride

C13H9ClO

结构：CON=C1C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C1

HCID58714586

未命名化合物

PRODUCTS

生成物

结构：CON=C1CC(C(=O)NCC(O)c2ccc(O)c(O)c2)N(C(=O)c2ccc(-c3ccccc3)cc2)C1

HCID131726384

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and 4-[(1RS)-2-amino-1-hydroxyethyl]-1,2-benzenediol, the title compound was obtained in 66% purity by HPLC. MS(ESI+): m/z=490.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9131700a2fb34a4f91c51b702f009bdc
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07211601B2
来源说明: uspto-grants-2007_05

反应 SMILES

C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:22](C(Cl)=O)=[CH:21][CH:20]=1.[NH2:34][CH2:35][CH:36]([C:38]1[CH:39]=[C:40]([OH:45])[C:41]([OH:44])=[CH:42][CH:43]=1)[OH:37]>>[C:28]1([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:29]=[CH:30][C:31]([C:6]([N:8]2[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][CH:9]2[C:16]([NH:34][CH2:35][CH:36]([C:38]2[CH:43]=[CH:42][C:41]([OH:44])=[C:40]([OH:45])[CH:39]=2)[OH:37])=[O:18])=[O:7])=[CH:32][CH:33]=1