(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 131725604, compound

HRID 1349263Notes

Reaction equation

HRID 1349263 reaction equation
C(OC([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=O)(C)(C)C.[C:19]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1.[C:35]1([C:41]2([OH:47])[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]([N:44]2[CH2:45][CH2:46][C:41]([OH:47])([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[CH2:42][CH2:43]2)=[O:18])[N:8]([S:25]([C:22]2[CH:23]=[CH:24][C:19]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:20][CH:21]=2)(=[O:27])=[O:26])[CH2:12]1

Participants

4

Reactant 3

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 963874-Phenylpiperidin-4-olHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725604HCID 131725604, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-sulfonyl chloride, and 4phenyl-4-piperidinol, the title compound was obtained in 84% purity by HPLC. MS(ESI+): m/z=534.

Sources & evidence

ORD record
ord-ca99366ffc344eafba7cc48c2a24dfa7
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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