HRID1349269

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID119881

未命名化合物

HCID1520811

4-PYRIDIN-4-YL-BENZOIC ACID

C12H9NO2

结构：CON=C1C[C@@H](C(=O)O)N(C(=O)OC(C)(C)C)C1

HCID58714586

(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

C11H18N2O5

PRODUCTS

生成物

结构：CON=C1C[C@@H](C(=O)N[C@@H](CO)[C@@H](O)c2ccccc2)N(C(=O)c2ccc(-c3ccncc3)cc2)C1

HCID131726395

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 4-(4-pyridinyl)benzoic acid, and (1S,2S)-2-amino-1-phenyl-1,3-propanediol, the title compound was obtained in 64% purity by HPLC. MS(ESI+): m/z=489.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4829ed91497444c980dbeb2d7f3ad0dd
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07211601B2
来源说明: uspto-grants-2007_05

反应 SMILES

C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[N:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:33]=[CH:32][C:28](C(O)=O)=[CH:27][CH:26]=2)=[CH:21][CH:20]=1.[NH2:34][C@@H:35]([CH2:44][OH:45])[C@H:36]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[OH:37]>>[OH:37][C@@H:36]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[C@@H:35]([NH:34][C:16]([C@@H:9]1[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]1[C:6](=[O:7])[C:28]1[CH:27]=[CH:26][C:25]([C:22]2[CH:21]=[CH:20][N:19]=[CH:24][CH:23]=2)=[CH:33][CH:32]=1)=[O:18])[CH2:44][OH:45]