(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 131726398, compound

HRID 1349277Notes

Reaction equation

HRID 1349277 reaction equation
C(OC([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=O)(C)(C)C.[C:19]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1.[NH2:35][C@H:36]1[C@H:41]2[CH2:42][C@H:38]([CH:39]=[CH:40]2)[C@H:37]1[C:43]([NH2:45])=[O:44]>>[NH2:45][C:43]([C@@H:37]1[C@@H:38]2[CH2:42][C@@H:41]([CH:40]=[CH:39]2)[C@@H:36]1[NH:35][C:16]([C@@H:9]1[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]1[S:25]([C:22]1[CH:23]=[CH:24][C:19]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:20][CH:21]=1)(=[O:27])=[O:26])=[O:18])=[O:44]

Participants

4

Reactant 3

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 11886826HCID 11886826, compoundHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726398HCID 131726398, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-sulfonyl chloride, and (1R,2R,3S,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide, the title compound was obtained in 83% purity by HPLC. MS(ESI+): m/z=509.

Sources & evidence

ORD record
ord-4ca474c789fa47faa6390de0a5212874
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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