(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 131726400, compound

HRID 1349280Notes

Reaction equation

HRID 1349280 reaction equation
C(OC([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=O)(C)(C)C.[C:19]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1.[NH2:35][C@H:36]1[C@H:41]2[CH2:42][C@H:38]([CH2:39][CH2:40]2)[C@H:37]1[CH2:43][OH:44]>>[C:19]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:22]([S:25]([N:8]2[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]2[C:16]([NH:35][C@@H:36]2[C@H:37]([CH2:43][OH:44])[C@@H:38]3[CH2:42][C@H:41]2[CH2:40][CH2:39]3)=[O:18])(=[O:27])=[O:26])=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 13202627HCID 13202627, compoundHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726400HCID 131726400, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-sulfonyl chloride, and [(1S,2R,3S,4R)-3-aminobicyclo[2.2.1]hept-2-yl]methanol, the title compound was obtained in 58% purity by HPLC. MS(ESI+): m/z=498.

Sources & evidence

ORD record
ord-4b98d96df7ad41b29ca47b344388ed09
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

Loading…