Gamma-Aminobutyric Acid → HCID 131725627, compound

HRID 1349288Notes

Reaction equation

HRID 1349288 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[C:19]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:22](C(Cl)=O)=[CH:21][CH:20]=1.[NH2:34][CH2:35][CH2:36][CH2:37][C:38]([OH:40])=[O:39]>>[C:28]1([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:29]=[CH:30][CH:31]=[CH:32][C:33]=1[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([NH:34][CH2:35][CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[O:18])=[O:7]

Participants

4

Reactant 3

HCID 119Gamma-Aminobutyric AcidHCID 841514-Phenylbenzoyl chlorideHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131725627HCID 131725627, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, [1,1′-biphenyl]-4-carbonyl chloride, and 4-aminobutanoic acid, the title compound was obtained in 57% purity by HPLC. MS(ESI+): m/z=424.

Sources & evidence

ORD record
ord-74b5bcb3b3d943e19c40003120233498
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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