2'-Methyl-biphenyl-4-carboxylic acid → HCID 131726404, compound

HRID 1349294Notes

Reaction equation

HRID 1349294 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[CH3:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[CH:31]=[CH:30][C:29](C(O)=O)=[CH:28][CH:27]=1.[NH2:35][C@H:36]1[C@H:41]2[CH2:42][C@H:38]([CH:39]=[CH:40]2)[C@H:37]1[C:43]([NH2:45])=[O:44]>>[NH2:45][C:43]([C@@H:37]1[C@@H:38]2[CH2:42][C@@H:41]([CH:40]=[CH:39]2)[C@@H:36]1[NH:35][C:16]([C@@H:9]1[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]1[C:6]([C:29]1[CH:28]=[CH:27][C:26]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH3:19])=[CH:31][CH:30]=1)=[O:7])=[O:18])=[O:44]

Participants

4

Reactant 3

HCID 27598152'-Methyl-biphenyl-4-carboxylic acidHCID 11886826HCID 11886826, compoundHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726404HCID 131726404, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-methyl[1,1′-biphenyl]-4-carboxylic acid, and (1R,2R,3S,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide, the title compound was obtained in 55% purity by HPLC. MS(ESI+): m/z=487.

Sources & evidence

ORD record
ord-667327a889db4ea194c45dab40ff8ea2
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

Loading…