2'-Methoxy-biphenyl-4-carboxylic acid → HCID 178502621, compound

HRID 1349302Notes

Reaction equation

HRID 1349302 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]1[CH:32]=[CH:31][C:30](C(O)=O)=[CH:29][CH:28]=1.[NH2:36][C@H:37]1[CH2:42][CH2:41][C@H:40]([OH:43])[CH2:39][CH2:38]1>>[OH:43][C@H:40]1[CH2:41][CH2:42][C@H:37]([NH:36][C:16]([C@@H:9]2[CH2:10][C:11](=[N:13][O:14][CH3:15])[CH2:12][N:8]2[C:6]([C:30]2[CH:29]=[CH:28][C:27]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[O:20][CH3:19])=[CH:32][CH:31]=2)=[O:7])=[O:18])[CH2:38][CH2:39]1

Participants

4

Reactant 3

HCID 27595482'-Methoxy-biphenyl-4-carboxylic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acidHCID 178511715HCID 178511715, compound

Product 1

HCID 178502621HCID 178502621, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-methoxy[1,1′-biphenyl]-4-carboxylic acid, and trans-4-aminocyclohexanol, the title compound was obtained in 61% purity by HPLC. MS(ESI+): m/z=466.

Sources & evidence

ORD record
ord-119ad73063d741b9b334c0dd266c062a
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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