1,2,3,4-Tetrahydroisoquinoline → (3Ez,5s)-5-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-1-[(2',3-dimethyl[1,1'-biphenyl]-4-yl)carbonyl]-3-pyrrolidinone o-methyloxime

Participants

Role	Name	HCID	Charge
Reactant	1,2,3,4-Tetrahydroisoquinoline	HCID 7046	—
Reactant	2',3-Dimethyl[1,1'-biphenyl]-4-carboxylic acid	HCID 21937246	—
Reactant	(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid	HCID 58714586	—
Product	(3Ez,5s)-5-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-1-[(2',3-dimethyl[1,1'-biphenyl]-4-yl)carbonyl]-3-pyrrolidinone o-methyloxime	HCID 131725654	—

Reaction Steps

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′,3-dimethyl[1,1′-biphenyl]-4-carboxylic acid, and 1,2,3,4-tetrahydroisoquinoline, the title compound was obtained in 77% purity by HPLC. MS(ESI+): m/z=482.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07211601B2
Source dataset	uspto-grants-2007_05
ORD ID	ord-cd0e0ce3b52447e8b4faefc70c572f80
Source note	uspto-grants-2007_05