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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1349329생성일: 2026년 10월 25일

2',3-Dimethyl[1,1'-biphenyl]-4-carboxylic acid → (2S,4EZ)-N-[(1R,2S)-2-(aminocarbonyl)cyclohexyl]-1-[(2',3-dimethyl[1,1'-biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamide

https://huagongshe.com/reaction/1349329

반응식

참여 물질

역할이름HCID투입량
반응물2',3-Dimethyl[1,1'-biphenyl]-4-carboxylic acidHCID 21937246—
반응물cis-2-Amino-1-cyclohexanecarboxamideHCID 30069035—
반응물(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acidHCID 58714586—
생성물(2S,4EZ)-N-[(1R,2S)-2-(aminocarbonyl)cyclohexyl]-1-[(2',3-dimethyl[1,1'-biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxamideHCID 131725661—

반응 단계

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′,3-dimethyl[1,1′-biphenyl]-4-carboxylic acid, and (1S,2R)-2-aminocyclohexanecarboxamide, the title compound was obtained in 91% purity by HPLC. MS(ESI+): m/z=491.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07211601B2
출처 데이터셋uspto-grants-2007_05
ORD IDord-1bd0d40260c344cc95ca3ed06b61dd8a
출처 메모uspto-grants-2007_05