1-(2-Hydroxyethyl)piperazine → HCID 131726419, compound

HRID 1349332Notes

Reaction equation

HRID 1349332 reaction equation
C(O[C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][C@H:9]1[C:16]([OH:18])=O)=[O:7])(C)(C)C.[CH3:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[C:21]=1[C:27]1[CH:32]=[CH:31][C:30](C(O)=O)=[CH:29][CH:28]=1.[N:36]1([CH2:42][CH2:43][OH:44])[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1>>[CH3:15][O:14][N:13]=[C:11]1[CH2:10][C@@H:9]([C:16]([N:39]2[CH2:40][CH2:41][N:36]([CH2:42][CH2:43][OH:44])[CH2:37][CH2:38]2)=[O:18])[N:8]([C:6]([C:30]2[CH:29]=[CH:28][C:27]([C:21]3[C:22]([CH3:26])=[CH:23][CH:24]=[CH:25][C:20]=3[CH3:19])=[CH:32][CH:31]=2)=[O:7])[CH2:12]1

Participants

4

Reactant 3

HCID 76771-(2-Hydroxyethyl)piperazineHCID 219372914-(2,6-Dimethylphenyl)benzoic acidHCID 58714586(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid

Product 1

HCID 131726419HCID 131726419, compound

Procedure

Following the general method as outlined in Example 22, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′,6′-dimethyl[1,1′-biphenyl]-4carboxylic acid, and 2-(1-piperazinyl)ethanol, the title compound was obtained in 79% purity by HPLC. MS(ESI+): m/z=479.

Sources & evidence

ORD record
ord-45cdc515eb1e4057ac2f619de4e28ccf
Source dataset
uspto-grants-2007_05
Patent number
US07211601B2

Reaction notes

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