Phosphate → 1,4-Dioxaspiro(4.5)decan-8-ol

Participants

Reaction Steps

350 g of 1,4-dioxa-spiro[4.5]decan-8-one were suspended in 2000 ml of ethanol, and 28.1 g of sodium borohydride were added in portions while cooling with an ice bath. After stirring overnight at room temperature, first 750 ml of phosphate buffer (pH 7, Merck-Darmstadt) and then 1000 ml of diethyl ether were added, with stirring, and precipitated solids were filtered and then washed with diethyl ether. The filtrate was dried over sodium sulfate, filtered and concentrated. 345 g of 1,4-dioxa-spiro[4.5]decan-8-ol were obtained in the form of a white solid.

Provenance & Evidence