Hydrochloric Acid → 4-(Dimethylamino)-4-phenylcyclohexan-1-one

Participants

Reaction Steps

165 ml of hydrochloric acid (32 wt. %) were diluted with 100 ml of water; 60.0 g of dimethyl-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amine were added to this approximately six molar hydrochloric acid, and stirring was carried out for 24 hours. The reaction mixture was washed three times using 50 ml of diethyl ether each time, rendered alkaline (pH>10) with 100 ml of sodium hydroxide solution (32 wt. %) and extracted three times using 100 ml of dichloromethane each time. The extracts were combined, dried over sodium sulfate, filtered and concentrated. 36.1 g of 4-dimethylamino-4-phenylcyclohexanone were obtained.

Provenance & Evidence