Hydrochloric Acid → 4-Benzyl-4-(dimethylamino)cyclohexanone

Participants

Reaction Steps

200 ml of hydrochloric acid (32 wt. %) were diluted with 120 ml of water; 78.4 g of crude (8-benzyl-1,4-dioxa-spiro[4.5]dec-8-yl)-dimethyl-amine were added to this approximately six molar hydrochloric acid, and stirring was carried out for 24 hours. The reaction mixture was washed three times using 100 ml of diethyl ether each time, rendered alkaline (pH>10) with 100 ml of sodium hydroxide solution (32 wt. %) while cooling with an ice bath, and extracted three times using 100 ml of dichloromethane each time. The extracts were combined, dried over sodium sulfate, filtered and concentrated. 50.4 g of 4-benzyl-4-dimethylamino-cyclohexanone were obtained.

Provenance & Evidence