Phosphate → HCID 21093239, compound

Participants

Reaction Steps

40.0 g of 4-benzyl-4-dimethylamino-cyclohexanone were suspended in 250 ml of isopropanol; 19.9 g of sodium boranate were added, while cooling with an ice bath, and stirring was carried out overnight at room temperature. 65 ml of phosphate buffer (pH 7, Merck-Darmstadt) were added dropwise and the mixture was concentrated. The residue was taken up in water and dichloromethane and rendered alkaline with potassium hydroxide. The phases were separated and extracted three times with dichloromethane. The combined organic phases were dried over sodium sulfate, filtered and concentrated. 37.7 g of 4-benzyl-4-dimethylaminocyclohexanol were obtained.

Provenance & Evidence