Fumaric Acid → HCID 131725031, compound

Participants

Reaction Steps

(2R)-1-[1,1-Dimethyl-2-(naphthalen-2-yl)ethylamino]-3-[(1R)-(cyclopropyl)[2-(hydroxymethyl)phenyl]methoxy]propan-2-ol (700 mg) obtained in Step 6 was dissolved in methanol (15 ml), and fumaric acid (94 mg) was added. The mixture was stirred for 30 min. The reaction mixture was concentrated under reduced pressure, and ether was added to the residue. The precipitated solid was collected by filtration to give the title compound (720 mg).

Provenance & Evidence