Triacetoxyperiodinane → HCID 23077588, compound

Participants

Reaction Steps

To a solution of 9-benzyloxy-2-(3,4-dichlorobenzyl)-6-hydroxymethyl-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (860 mg) obtained in Example 5, Step 6 in chloroform (80 ml) was added Dess-Martin reagent (843 mg). After stirring at room temperature for 1 hr, the solvent was evaporated and chloroform (50 ml) was added to the obtained residue and a solid product was filtered off. The filtrate was concentrated and purified by silica gel column chromatography (chloroform:acetone=1:2) to give 9-benzyloxy-2-(3,4-dichlorobenzyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-6-carbaldehyde (621 mg).

Provenance & Evidence