HCID 23077639, compound → HCID 54683300, compound

Participants

Reaction Steps

9-Benzyloxy-2-(3-chlorobenzyl)-7-(2,2-dimethylpropionyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (43 mg) was dissolved in trifluoroacetic acid (2 ml) and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated and toluene was added, and the mixture was concentrated again. Subsequently, a suitable amount of hydrochloric acid/ethyl acetate solution was added, and the mixture was concentrated again. Ethyl acetate (0.6 ml)-diisopropyl ether (1 ml) was added to the obtained residue and the obtained solid was collected by filtration to give 2-(3-chlorobenzyl)-7-(2,2-dimethylpropionyl)-9-hydroxy-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione hydrochloride (25.6 mg).

Provenance & Evidence