Tris(furan-2-yl)phosphane → HCID 23077584, compound

Participants

Role	Name	HCID	Charge
Reactant	Tris(furan-2-yl)phosphane	HCID 521585	—
Reactant	2-(Tributylstannyl)-1,3-thiazole	HCID 2763259	—
Reactant	HCID 23077618	HCID 23077618	—
Catalyst	Palladium, tris[mu-[(1,2-eta:4,5-eta)-(1E,4E)-1,5-diphenyl-1,4-pentadien-3-one]]di-, compd. with trichloromethane (1:1)	HCID 11029508	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 23077584	HCID 23077584	—

Reaction Steps

To a solution of 9-benzyloxy-7-bromo-2-(3,4-dichlorobenzyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (150 mg) in dioxane (5 ml) were added tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct (63 mg), tri-2-furylphosphine (57 mg) and (2-thiazolyl)tributyltin (0.285 ml) under an argon stream and a microwave at 80 W was irradiated under sealing for 1 hr. The obtained reaction mixture was concentrated, and then purified by silica gel column chromatography (chloroform:methanol=40:1) to give 9-benzyloxy-2-(3,4-dichlorobenzyl)-7-(thiazol-2-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (95 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07211572B2
Source dataset	uspto-grants-2007_05
ORD ID	ord-e8a389388c08435ba44723af7f147eb3
Source note	uspto-grants-2007_05