HCID 23077584, compound → HCID 54683432, compound

Participants

Reaction Steps

9-Benzyloxy-2-(3,4-dichlorobenzyl)-7-(thiazol-2-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (93 mg) was dissolved in trifluoroacetic acid (2 ml). After leaving at room temperature for 1.5 hr, the mixture was concentrated. Toluene was added to the residue and the mixture was concentrated again, which operations were performed twice. Ethyl acetate was added and the solid was collected by filtration to give 2-(3,4-dichlorobenzyl)-9-hydroxy-7-(thiazol-2-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (53 mg).

Provenance & Evidence