1,4-Dioxane hydrochloride → HCID 23077599, compound

Participants

Reaction Steps

To a solution of tert-butyl [9-benzyloxy-2-(3-chloro-4-fluorobenzyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl]carbamate (179 mg) in dioxane (2 ml) was added 4N hydrochloric acid/dioxane solution (2 ml) and the mixture was stirred at room temperature for 3.5 hr. The solvent was evaporated and aqueous sodium hydrogen carbonate solution was added to the obtained residue. The mixture was extracted with chloroform. The chloroform layer was dried, concentrated and purified by silica gel column chromatography (ethyl acetate:methanol=5:1) to give 7-amino-9-benzyloxy-2-(3-chloro-4-fluorobenzyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (88 mg).

Provenance & Evidence