Methanesulfonyl chloride → HCID 54683523, compound

HRID 1349508Notes

Reaction equation

[NH2:1][C:2]1[C:3](=[O:30])[C:4]([O:22]CC2C=CC=CC=2)=[C:5]2[C:10](=[O:11])[N:9]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([F:19])=[C:15]([Cl:20])[CH:14]=3)[CH2:8][CH2:7][N:6]2[CH:21]=1.[CH3:31][S:32](Cl)(=[O:34])=[O:33]>>[Cl:20][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][C:16]=1[F:19])[CH2:12][N:9]1[CH2:8][CH2:7][N:6]2[CH:21]=[C:2]([NH:1][S:32]([CH3:31])(=[O:34])=[O:33])[C:3](=[O:30])[C:4]([OH:22])=[C:5]2[C:10]1=[O:11]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 23077599HCID 23077599, compound

Product 1

HCID 54683523HCID 54683523, compound

Procedure

By subjecting 7-amino-9-benzyloxy-2-(3-chloro-4-fluorobenzyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (29 mg) obtained in Example 349, Step 2 to a reaction operation similar to that in Example 349, Steps 3 and 4 except that methanesulfonyl chloride was used instead of isobutyryl chloride, N-[2-(3-chloro-4-fluorobenzyl)-9-hydroxy-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazin-7-yl]methanesulfonamide (4.7 mg) was obtained.

Sources & evidence

ORD record: ord-31f1bacea8614923bea57d53c79d29a0
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07211572B2

Reaction notes

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