HCID 23077550, compound → HCID 54705338, compound

Participants

Reaction Steps

9-Benzyloxy-2-(3,4-difluorobenzyl)-7-(thiazol-2-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (35 mg) was dissolved in trifluoroacetic acid (1 ml) and the mixture was stirred at room temperature for 3 hr. Trifluoroacetic acid was evaporated under reduced pressure, toluene was added to the obtained residue and the mixture was concentrated, which operations were performed twice. Ethyl acetate was further added and the obtained solid was collected by filtration to give 2-(3,4-difluorobenzyl)-9-hydroxy-7-(thiazol-2-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione (14 mg).

Provenance & Evidence