Acetyl chloride → HCID 86592017, compound

HRID 1349533Notes

Reaction equation

C(N)(=O)CC.[CH3:6][C@H:7]1[CH2:16][C@@H:15]([N:17]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:18](=[O:21])[CH2:19][CH3:20])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]1[C:28]([C:30]1[O:31][C:32]([C:35]2[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=2)=[CH:33][CH:34]=1)=[O:29].O1C=CC=C1C(Cl)=O.C(Cl)(=O)CC.C(Cl)(=O)C>>[CH3:6][C@H:7]1[CH2:16][C@@H:15]([N:17]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:18](=[O:21])[CH2:19][CH3:20])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]1[C:28]([C:30]1[O:31][C:32]([C:35]2[CH:36]=[CH:37][C:38]([N+:41]([O-:43])=[O:42])=[CH:39][CH:40]=2)=[CH:33][CH:34]=1)=[O:29]

Participants

Reactant 4

HCID 6367Acetyl chloride

HCID 62324Propionyl chloride

HCID 682422-Furancarbonyl chloride

HCID 86592018HCID 86592018, compound

Product 1

HCID 86592017HCID 86592017, compound

Procedure

(±)-Cis-N-{2-methyl-1-[5-(4-nitro-phenyl)-furan-2-carbonyl]-1,2,3,4-tetrahydro-quinolin-4-yl}-N-phenyl-propionamide propionamide was made following general procedure A, substituting 5-(4-nitro-phenyl)-furan-2-carbonyl chloride for 2-furoyl chloride and propionyl chloride for acetyl chloride.

Sources & evidence

ORD record: ord-f3521e9b30764023b0262bbce68d7dee
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07211672B2

Reaction notes

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