HRID1349557

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(F)cc2)c2ccc(OCC(N)=O)cc21

HCID86592035

未命名化合物

结构：CCOC(=O)COc1ccc2c(c1)N(C(=O)c1ccc(N(C)C)cc1)[C@@H](C)C[C@H]2N(C(C)=O)c1ccc(Cl)cc1

HCID86592045

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(N(C)C)cc2)c2cc(OCC(N)=O)ccc21

HCID58859789

未命名化合物

PROCEDURE

实验过程

(±)-Cis-2-[4-[acetyl-(4-chloro-phenyl)-amino]-1-(4-dimethylamino-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-7-yloxy]-acetamide was prepared from (±)-cis-[4-[acetyl-(4-chloro-phenyl)-amino]-1-(4-dimethylamino-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-7-yloxy]-acetic acid ethyl ester, via the same amidation procedure used in the synthesis of (±)-cis-N-[6-carbamoylmethoxy-1-(4-fluoro-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-4-yl]-N-(4-chloro-phenyl)-propionamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0211e9e52ade428cb3d488f76a23ee94
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07211672B2
来源说明: uspto-grants-2007_05

反应 SMILES

C([O:3][C:4](=O)[CH2:5][O:6][C:7]1[CH:16]=[C:15]2[C:10]([C@H:11]([N:29]([C:37](=[O:39])[CH3:38])[C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)[CH2:12][C@H:13]([CH3:28])[N:14]2[C:17](=[O:27])[C:18]2[CH:23]=[CH:22][C:21]([N:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)C.C(COC1C=C2C(=CC=1)N(C(=O)C1C=CC(F)=CC=1)[C@@H](C)C[C@H]2N(C1C=CC(Cl)=CC=1)C(=O)CC)(=O)[NH2:42]>>[C:37]([N:29]([C:30]1[CH:31]=[CH:32][C:33]([Cl:36])=[CH:34][CH:35]=1)[C@H:11]1[C:10]2[C:15](=[CH:16][C:7]([O:6][CH2:5][C:4]([NH2:42])=[O:3])=[CH:8][CH:9]=2)[N:14]([C:17](=[O:27])[C:18]2[CH:23]=[CH:22][C:21]([N:24]([CH3:25])[CH3:26])=[CH:20][CH:19]=2)[C@@H:13]([CH3:28])[CH2:12]1)(=[O:39])[CH3:38]